BRCA-1 and BRCA-2 mutations as prognostic factors in clinical practice and genetic counselling.

@article{Nicoletto2001BRCA1AB,
  title={BRCA-1 and BRCA-2 mutations as prognostic factors in clinical practice and genetic counselling.},
  author={Maria Ornella Nicoletto and Martin Edward Donach and Arcangela De Nicolo and Grazia Artioli and Giuseppe L. Banna and Silvio Monfardini},
  journal={Cancer treatment reviews},
  year={2001},
  volume={27 5},
  pages={295-304}
}
Women in general have a 10% risk of developing breast cancer and a 2-3% chance of ovarian cancer in their life-times. Mutations in BRCA-1 and BRCA-2 are present in only a small portion (5-10%) of all breast cancers. Carriers of mutations in these genes have a greater risk of cancer, especially before menopause in the case of BRCA-1 carriers. In addition, their risk of contralateral breast cancer is significantly higher than for the general population (4.2-53% vs. 2%). The grade of contralateral… CONTINUE READING

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Patients with these mutations are referred for genetic counselling , a complex process which includes : an informative dialogue between the proband and the geneticist , drawing up a family history , informed consent , evaluation of risk , genetic testing and possible involvement of healthy family members .
Patients with these mutations are referred for genetic counselling , a complex process which includes : an informative dialogue between the proband and the geneticist , drawing up a family history , informed consent , evaluation of risk , genetic testing and possible involvement of healthy family members .
Patients with these mutations are referred for genetic counselling , a complex process which includes : an informative dialogue between the proband and the geneticist , drawing up a family history , informed consent , evaluation of risk , genetic testing and possible involvement of healthy family members .
Patients with these mutations are referred for genetic counselling , a complex process which includes : an informative dialogue between the proband and the geneticist , drawing up a family history , informed consent , evaluation of risk , genetic testing and possible involvement of healthy family members .
Patients with these mutations are referred for genetic counselling , a complex process which includes : an informative dialogue between the proband and the geneticist , drawing up a family history , informed consent , evaluation of risk , genetic testing and possible involvement of healthy family members .
Patients with these mutations are referred for genetic counselling , a complex process which includes : an informative dialogue between the proband and the geneticist , drawing up a family history , informed consent , evaluation of risk , genetic testing and possible involvement of healthy family members .
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