BRCA 1 Functions as a Differential Modulator of Chemotherapy-induced Apoptosis 1

@inproceedings{Quinn2003BRCA1F,
  title={BRCA 1 Functions as a Differential Modulator of Chemotherapy-induced Apoptosis 1},
  author={Jennifer E. Quinn and Richard D. Kennedy and Paul Mullan and Paula M. Gilmore and Michael P. Carty and Patrick Gerard Johnston and Denis Paul Harkin},
  year={2003}
}
We have evaluated the role played by BRCA1 in mediating the phenotypic response to a range of chemotherapeutic agents commonly used in cancer treatment. Here we provide evidence that BRCA1 functions as a differential mediator of chemotherapy-induced apoptosis. Specifically, we demonstrate that BRCA1 mediates sensitivity to apoptosis induced by… CONTINUE READING