BRAM1, a BMP receptor‐associated molecule involved in BMP signalling

@article{Kurozumi1998BRAM1AB,
  title={BRAM1, a BMP receptor‐associated molecule involved in BMP signalling},
  author={Kimikazu Kurozumi and Michiru Nishita and Kyoko Yamaguchi and Takashi Fujita and Naoto Ueno and Hiroshi Shibuya},
  journal={Genes to Cells},
  year={1998},
  volume={3}
}
TGF‐β superfamily members elicit signals through the stimulation of serine/threonine‐kinase receptors. Recently, molecules associated with several TGF‐β family receptors have been cloned. One such molecule, the immunophilin FKBP12, has been reported to interact with TGF‐β family type I receptors. However, the identity of signalling specific molecules interacting with the receptor was unknown. 

BIP, a BRAM‐interacting protein involved in TGF‐β signalling, regulates body length in Caenorhabditis elegans

A novel family member, BMP receptor associated molecule (BRAM), which binds to the intracellular domain of BMP type IA receptor and is involved in the BMP signalling pathway is identified.

Negative regulation of TGF-β signaling in development

The negative regulation of TGF-β signaling is reviewed with focus on its roles in vertebrate development and many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms.

TGF-β signaling in C. elegans *

Two of the ligands, DBL-1 and DAF-7, signal through a canonical receptor-Smad signaling pathway; while a third ligand, UNC-129, interacts with a noncanonical signaling pathway.

TGF-beta and the Smad signal transduction pathway.

  • A. MehraJ. Wrana
  • Biology
    Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 2002
Smads have emerged as multifunctional transmitters of TGF-beta family signals that play critical roles in the development and homeostasis of metazoans.

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.

Findings indicate a new inhibitory function of FKBP12 as an adaptor molecule for the Smad7-Smurf1 complex to regulate the duration of the activin signal.

A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-β signaling

It is proposed that BRA-1 represents a novel class of receptor-associated molecules that negatively regulate transforming growth factor-β pathways and exhibits robust suppression of the Daf-c phenotype caused by the DAF-7 pathway mutations.

Bone morphogenetic protein signaling is fine-tuned on multiple levels

The receptors for ligands of the bone morphogenetic protein (BMP) family translate signals from the outside to the inside of the cell through numerous stages and checkpoints, which are depicted in the following paragraphs.

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

  • E. PiekC. HeldinP. ten Dijke
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
This work will focus on recent insights into the molecular mechanisms by which signaling specificity between different TGF-beta superfamily members is achieved and regulated, and how a single family member can elicit a broad scala of biological responses.
...

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