BRAM1, a BMP receptor‐associated molecule involved in BMP signalling

  title={BRAM1, a BMP receptor‐associated molecule involved in BMP signalling},
  author={Kimikazu Kurozumi and Michiru Nishita and Kyoko Yamaguchi and Takashi Fujita and Naoto Ueno and Hiroshi Shibuya},
  journal={Genes to Cells},
TGF‐β superfamily members elicit signals through the stimulation of serine/threonine‐kinase receptors. Recently, molecules associated with several TGF‐β family receptors have been cloned. One such molecule, the immunophilin FKBP12, has been reported to interact with TGF‐β family type I receptors. However, the identity of signalling specific molecules interacting with the receptor was unknown. 

BIP, a BRAM‐interacting protein involved in TGF‐β signalling, regulates body length in Caenorhabditis elegans

A novel family member, BMP receptor associated molecule (BRAM), which binds to the intracellular domain of BMP type IA receptor and is involved in the BMP signalling pathway is identified.

Negative regulation of TGF-β signaling in development

The negative regulation of TGF-β signaling is reviewed with focus on its roles in vertebrate development and many modulators have been found to contribute to a tight regulation of this pathway in a variety of mechanisms.

TGF-β signaling in C. elegans *

Two of the ligands, DBL-1 and DAF-7, signal through a canonical receptor-Smad signaling pathway; while a third ligand, UNC-129, interacts with a noncanonical signaling pathway.

TGF-beta and the Smad signal transduction pathway.

  • A. MehraJ. Wrana
  • Biology
    Biochemistry and cell biology = Biochimie et biologie cellulaire
  • 2002
Smads have emerged as multifunctional transmitters of TGF-beta family signals that play critical roles in the development and homeostasis of metazoans.

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor.

Findings indicate a new inhibitory function of FKBP12 as an adaptor molecule for the Smad7-Smurf1 complex to regulate the duration of the activin signal.

A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-β signaling

It is proposed that BRA-1 represents a novel class of receptor-associated molecules that negatively regulate transforming growth factor-β pathways and exhibits robust suppression of the Daf-c phenotype caused by the DAF-7 pathway mutations.

Bone morphogenetic protein signaling is fine-tuned on multiple levels

The receptors for ligands of the bone morphogenetic protein (BMP) family translate signals from the outside to the inside of the cell through numerous stages and checkpoints, which are depicted in the following paragraphs.

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

  • E. PiekC. HeldinP. ten Dijke
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
This work will focus on recent insights into the molecular mechanisms by which signaling specificity between different TGF-beta superfamily members is achieved and regulated, and how a single family member can elicit a broad scala of biological responses.



Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

DPC4 is essential for the function of Smadl and Smad2 in pathways that signal mesoderm induction and patterning in Xenopus embryos, as well as antimitogenic and transcriptional responses in breast epithelial cells.

Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

Examination of the role of TAK1 and TAB1 in the dorsoventral patterning of early Xenopus embryos suggests that xTAK1 and xTAB1 function in the BMP signal transduction pathway in xenopus embryos in a cooperative manner.

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-β, and increased the kinase activity of TAK1.

A human Mad protein acting as a BMP-regulated transcriptional activator

The cloned Smad1, a human homologue of Mad and Sma, is cloned and it is suggested that the Smad proteins are a new class of transcription factors that mediate responses to the TGF-β family.

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

Results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.

The p21RAS Farnesyltransferase α Subunit in TGF-β and Activin Signaling

The growth inhibitory and differentiative pathways activated by TGF-β and activin involve novel mechanisms of serine-threonine receptor phosphorylation-dependent release of cytoplasmic interactors and regulation of the activation of small G proteins, such as p21RAS.

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.

Overproduction of TAB1 enhanced activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increased the kinase activity of TAK1.

Activation of signalling by the activin receptor complex

The evidence suggests thatactR-IIB acts as a primary activin receptor and ActR-IB acts as an upstream transducer of activin signals, suggesting that this domain contains phosphorylation sites required for signalling.