BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration.

@article{Flockhart2012BRAFV600ERT,
  title={BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration.},
  author={Ross J. Flockhart and Dan E. Webster and Kun Qu and Nicholas Mascarenhas and Joanna R. Kovalski and Markus Kretz and Paul A. Khavari},
  journal={Genome research},
  year={2012},
  volume={22 6},
  pages={1006-14}
}
Aberrations of protein-coding genes are a focus of cancer genomics; however, the impact of oncogenes on expression of the ~50% of transcripts without protein-coding potential, including long noncoding RNAs (lncRNAs), has been largely uncharacterized. Activating mutations in the BRAF oncogene are present in >70% of melanomas, 90% of which produce active mutant BRAF(V600E) protein. To define the impacts of oncogenic BRAF on the melanocyte transcriptome, massively parallel cDNA sequencing (RNA-seq… CONTINUE READING
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