BRAFV600E mutation in the pathogenesis of a large series of papillary thyroid carcinoma in Czech Republic.

@article{Skorov2010BRAFV600EMI,
  title={BRAFV600E mutation in the pathogenesis of a large series of papillary thyroid carcinoma in Czech Republic.},
  author={Vlasta S{\'y}korov{\'a} and S{\'a}rka Dvoř{\'a}kov{\'a} and Ale{\vs} Ry{\vs}ka and Josef Vcelak and Eli{\vs}ka V{\'a}clav{\'i}kov{\'a} and Jan Laco and Daniela Kodetov{\'a} and R. Kodet and Adrian Cibula and Jaroslava Du{\vs}kov{\'a} and Alice Hlobilkov{\'a} and Jarom{\'i}r Astl and David G Vesely and Jan Betka and Jiř{\'i} Hoch and Svatopluk Smutn{\'y} and Jir{\'i} C{\'a}p and Petr Vl{\vc}ek and Zdenek Novak and Bela Bendlova},
  journal={Journal of endocrinological investigation},
  year={2010},
  volume={33 5},
  pages={318-24}
}
BACKGROUND Activating point mutation of the BRAF gene, the most common genetic alteration reported in papillary thyroid carcinomas (PTC), has been associated with poor prognostic characteristics. AIM Our objective was to determine the frequency of BRAFV600E mutation in PTC tumor tissues from the period 1960-2007 and to correlate it with clinicopathological parameters. SUBJECTS AND METHODS DNAs were extracted from 242 PTCs, 23 sporadic medullary carcinomas, one anaplastic carcinoma and 6… CONTINUE READING

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