BRAFV600E mutation, TIMP-1 upregulation, and NF-κB activation: closing the loop on the papillary thyroid cancer trilogy.

@article{Bommarito2011BRAFV600EMT,
  title={BRAFV600E mutation, TIMP-1 upregulation, and NF-κB activation: closing the loop on the papillary thyroid cancer trilogy.},
  author={Alessandra Bommarito and Pierina Richiusa and Elvira Carissimi and Giuseppe Pizzolanti and Vito Rodolico and Giovanni Zito and Angela Criscimanna and Francesco Di Blasi and Maria Pitrone and Monica Zerilli and Marco Calogero Amato and G. Spinelli and Valeria Carina and Giuseppe Modica and Mario Adelfio Latteri and Aldo Galluzzo and Carla Giordano},
  journal={Endocrine-related cancer},
  year={2011},
  volume={18 6},
  pages={669-85}
}
BRAF(V600E) is the most common mutation found in papillary thyroid carcinoma (PTC). Tissue inhibitor of metalloproteinases (TIMP-1) and nuclear factor (NF)-κB have been shown to play an important role in thyroid cancer. In particular, TIMP-1 binds its receptor CD63 on cell surface membrane and activates Akt signaling pathway, which is eventually responsible for its anti-apoptotic activity. The aim of our study was to evaluate whether interplay among these three factors exists and exerts a… CONTINUE READING
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