BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.

@article{Bradley2015BRAFV600ECA,
  title={BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.},
  author={Sherille D Bradley and Zeming Chen and Brenda D. Melendez and A. B. M. Hasan Talukder and Jahan S. Khalili and Tania G. Rodr{\'i}guez-Cruz and Shujuan Liu and Mayra Whittington and Wanleng Deng and Fenge Li and Chantale Bernatchez and Laszlo G. Radvanyi and Michael A. Davies and Patrick Hwu and Gregory A. Lizee},
  journal={Cancer immunology research},
  year={2015},
  volume={3 6},
  pages={
          602-9
        }
}
Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma, oncogenic BRAF(V600E) has been shown to drive the transcription of a specific gene signature that can promote multiple mechanisms of immune suppression within the tumor microenvironment. We show here that BRAF(V600E) also induces rapid internalization of MHC class I (MHC-I) from the melanoma cell surface and its intracellular… CONTINUE READING
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