BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas.

@article{Lima2004BRAFMA,
  title={BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas.},
  author={Jorge Lima and V{\'i}tor Trovisco and Paula Soares and Valdemar M{\'a}ximo and Jo{\~a}o Em{\'i}lio de Souza Magalh{\~a}es and Giuliana Salvatore and Massimo Santoro and Tatyana I. Bogdanova and Mykola D. Tronko and Alexander Y Abrosimov and Steve Jeremiah and Gerry Thomas and Dillwyn Williams and Manuel Sobrinho-Sim{\~o}es},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 9},
  pages={4267-71}
}
The BRAF gene has been shown to be a major target for mutations in papillary thyroid carcinoma (PTC) (36-69%), which forms almost all of the over 2000 cases of thyroid carcinoma that have occurred in Chernobyl. BRAF is activated by point mutation, and were it to occur at a high frequency in Chernobyl-related tumors, it would challenge the dominant role of double-strand breaks in radiation-induced PTC. In a previous study, we detected the BRAF V600E mutation in 46% (23 of 50) of sporadic adult… CONTINUE READING
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