BRAF mutation testing in solid tumors: a methodological comparison.

@article{Weyant2014BRAFMT,
  title={BRAF mutation testing in solid tumors: a methodological comparison.},
  author={Grace W. Weyant and Jeffrey D Wisotzkey and Floyd A Benko and Keri J. Donaldson},
  journal={The Journal of molecular diagnostics : JMD},
  year={2014},
  volume={16 5},
  pages={481-5}
}
Solid tumor genotyping has become standard of care for the characterization of proto-oncogene mutational status, which has traditionally been accomplished with Sanger sequencing. However, companion diagnostic assays and comparable laboratory-developed tests are becoming increasingly popular, such as the cobas 4800 BRAF V600 Mutation Test and the INFINITI KRAS-BRAF assay, respectively. This study evaluates and validates the analytical performance of the INFINITI KRAS-BRAF assay and compares… CONTINUE READING