BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer

  title={BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer},
  author={Eddy H J van Roon and Arnoud Boot and Ashwin A. Dihal and Robert Frans Ernst and Tom van Wezel and Hans M Morreau and Judith M. Boer},
  booktitle={Clinical Epigenetics},
Cancer-specific hypermethylation of (promoter) CpG islands is common during the tumorigenesis of colon cancer. Although associations between certain genetic aberrations, such as BRAF mutation and microsatellite instability, and the CpG island methylator phenotype (CIMP), have been found, the mechanisms by which these associations are established are still unclear. We studied genome-wide DNA methylation differences between colorectal tumors carrying a BRAF mutation and BRAF wildtype tumors… CONTINUE READING
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