BRAF mutation in papillary thyroid carcinoma.

@article{Cohen2003BRAFMI,
  title={BRAF mutation in papillary thyroid carcinoma.},
  author={Y. Cohen and M. Xing and E. Mambo and Z. Guo and G. Wu and B. Trink and U. Beller and W. Westra and P. Ladenson and D. Sidransky},
  journal={Journal of the National Cancer Institute},
  year={2003},
  volume={95 8},
  pages={
          625-7
        }
}
The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27 bladder, 38 cervical, and 17 prostate cancers, for the BRAF T1796A mutation by polymerase chain reaction (PCR)-restriction enzyme analysis of BRAF exon 15. In 24 (69%) of the 35 papillary thyroid carcinomas examined, we found a missense thymine (T)-->adenine (A) transversion at nucleotide 1796 in the… Expand
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[BRAF initiating mutations in the papillary thyroid carcinoma].
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BRAF T1796A transversion mutation in various thyroid neoplasms.
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