BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis.

@article{Mitsutake2006BRAFMR,
  title={BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis.},
  author={Norisato Mitsutake and Makoto Miyagishi and Shin Mitsutake and Nagako Akeno and Cl{\'e}o O Mesa and Jeffrey A. Knauf and Lei Zhang and K. Taira and James A. Fagin},
  journal={Endocrinology},
  year={2006},
  volume={147 2},
  pages={1014-9}
}
In human papillary thyroid cancers (PTCs), mutations of RET/PTC, NTRK, RAS, or BRAF are found in about two thirds of cases with practically no overlap, providing genetic evidence that constitutive signaling along RET-RAS-BRAF-MAPK is key to their development. The requirement for BRAF in RET/PTC-mediated MAPK activation and gene expression has not been tested functionally. There are three RAF isoforms: ARAF, BRAF, and CRAF. Compared with the others, ARAF is a much weaker stimulator of MAPK. To… CONTINUE READING

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