BRAF inhibitors: the current and the future.

  title={BRAF inhibitors: the current and the future.},
  author={Weijiang Zhang},
  journal={Current opinion in pharmacology},
The introduction of BRAF inhibitors (BRAFi), vemurafenib and dabrafenib, revolutionized BRAFV600-mutated metastatic melanoma treatment with improved response rate and overall survival compared to standard chemotherapy. However, the mechanism related cutaneous toxicity remains a concern. In addition, intrinsic and acquired resistance remain the key challenges in BRAFi therapy. Extensive efforts to elucidate the mechanisms have led to an improved understanding of disease biology and resulted in… CONTINUE READING

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