BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study.

@article{Casula2004BRAFGI,
  title={BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study.},
  author={Milena Casula and Maria Colombino and Maria Paola Satta and Antonio Cossu and Paolo Antonio Ascierto and Giovanna Bianchi-Scarr{\'a} and Daniele Castiglia and Mario Budroni and Carla Rozzo and Antonella Manca and Amelia Lissia and Annangela Carboni and Elisabetta Petretto and Sabrina M. R. Satriano and Gerardo Botti and Michela Mantelli and Paola Ghiorzo and Michael R. Stratton and Francesco Tanda and Giuseppe Palmieri},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2004},
  volume={22 2},
  pages={286-92}
}
PURPOSE Ocogenic activation of the BRAF gene has been demonstrated to be involved in the pathogenesis of malignant melanoma (MM). In this study, we investigated the contribution of BRAF to melanoma susceptibility, also making a comparison with frequency of CDKN2A germline mutations in MM patients from different areas in Italy. PATIENTS AND METHODS sing a combination of denaturing high-performance liquid chromatography analysis and automated sequencing on genomic DNA from peripheral blood or… CONTINUE READING

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