BRAF and RAS Mutations in Human Lung Cancer and Melanoma 1

@inproceedings{Brose2002BRAFAR,
  title={BRAF and RAS Mutations in Human Lung Cancer and Melanoma 1},
  author={Marcia S. Brose and Patricia Volpe and Michael Feldman and Madhu Kumar and Irum Rishi and Renee M Gerrero and Eugene Einhorn and Meenhard Herlyn and John D. Minna and A. Nicholson and J. L. A. Roth and Steven M. Albelda and Helen Margaret Davies and Charles J. Cox and Graham Brignell and Philip J. Stephens and P. Andrew Futreal and Richard Wooster and Michael R. Stratton and Barbara L. Weber},
  year={2002}
}
BRAF encodes a RAS-regulated kinase that mediates cell growth and malignant transformation kinase pathway activation. Recently, we have identified activating BRAF mutations in 66% of melanomas and a smaller percentage of many other human cancers. To determine whether BRAF mutations account for the MAP kinase pathway activation common in non-small cell lung… CONTINUE READING