BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy

@inproceedings{Colombino2012BRAFAP,
  title={BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy},
  author={Maria Colombino and Pasquale Sperlongano and Francesco Izzo and Fabiana Tatangelo and Gerardo Botti and Angela Lombardi and Mariasofia Accardo and Lucia Tarantino and Ignazio M. F. Sordelli and Michael Agresti and Alberto Abbruzzese and Michele Caraglia and Gabriella Palmieri},
  booktitle={Cell Death and Disease},
  year={2012}
}
Poor data have been previously reported about the mutation rates in K-RAS, BRAF, and PIK3CA genes among patients with hepatocellular carcinoma (HCC). Here we further elucidated the role of these genes in pathogenesis of primary hepatic malignancies. Archival tumour tissue from 65 HCC patients originating from South Italy were screened for mutations in these candidate genes by direct sequencing. Overall, oncogenic mutations were detected in 15 (23%) patients for BRAF gene, 18 (28%) for PIK3CA… CONTINUE READING
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