BRAF and NRAS Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer.


Purpose: Somatic mutation status at KRAS, BRAF, and NRAS is associated with prognosis in patients with advanced colorectal cancer (aCRC); however, it remains unclear whether there are intralocus, variant-specific differences in survival and other clinicopathologic parameters.Experimental Design: We profiled 2,157 aCRCs for somatic mutations in KRAS, BRAF… (More)
DOI: 10.1158/1078-0432.CCR-16-1541