BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas.

@article{Schnleben2007BRAFAK,
  title={BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas.},
  author={Frank Sch{\"o}nleben and Wanglong Qiu and Karl C Bruckman and Nancy T Ciau and Xiaojun Li and Margaret H Lauerman and Harold A. Frucht and John A. Chabot and J. D. F. Allendorf and Helen Remotti and Gloria H. Su},
  journal={Cancer letters},
  year={2007},
  volume={249 2},
  pages={242-8}
}
The Raf/MEK/ERK (MAPK) signal transduction is an important mediator of a number of cellular fates including growth, proliferation, and survival. The BRAF gene is activated by oncogenic RAS, leading to cooperative effects in cells responding to growth factor signals. Our study was performed to elucidate a possible role of BRAF in the development of IPMN (Intraductal Papillary Mucinous Neoplasm) and IPMC (Intraductal Papillary Mucinous Carcinoma) of the pancreas. Mutations of BRAF and KRAS were… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

Similar Papers

Loading similar papers…