BRAF V600E mutation in papillary thyroid carcinoma: significant association with node metastases and extra thyroidal invasion.

@article{Chakraborty2012BRAFVM,
  title={BRAF V600E mutation in papillary thyroid carcinoma: significant association with node metastases and extra thyroidal invasion.},
  author={Avik Chakraborty and Archana A Narkar and Rita Mukhopadhyaya and Shubhada N. Kane and Anil D'cruz and Mysore Govinda Ramakrishna Rajan},
  journal={Endocrine pathology},
  year={2012},
  volume={23 2},
  pages={83-93}
}
B-Raf (BRAF) is the strongest activator in the downstream of MAP kinase signaling. The somatic point mutation of BRAF gene (V600E) is the most common and specific event in papillary thyroid carcinoma (PTC). However, its prevalence is variable among different studies and its association with clinico-pathological features is controversial. This study tests the prevalence of BRAF (V600E) mutation in thyroid cancer patients in Indian subcontinental population. We analyzed 140 thyroid tumor… CONTINUE READING

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