BRAF V600E mutation in hairy cell leukemia: from bench to bedside.

  title={BRAF V600E mutation in hairy cell leukemia: from bench to bedside.},
  author={Brunangelo Falini and Maria Paola Martelli and Enrico Tiacci},
  volume={128 15},
Hairy cell leukemia (HCL) is a distinct clinicopathological entity whose underlying genetic lesion has remained a mystery for over half a century. The BRAF V600E mutation is now recognized as the causal genetic event of HCL because it is somatic, present in the entire tumor clone, detectable in almost all cases at diagnosis (encompassing the whole disease spectrum), and stable at relapse. BRAF V600E leads to the constitutive activation of the RAF-MEK-extracellular signal-regulated kinase (ERK… CONTINUE READING
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High prevalence of MAP2K1 mutations in variant and 1926 FALINI et al BLOOD, 13 OCTOBER 2016 x VOLUME 128, NUMBER 15 For personal use

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