BRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay

Abstract

BACKGROUND BRAF (V-raf murine sarcoma viral oncogene homolog B1) is a serine-threonine protein kinase involved in cell survival, proliferation, and differentiation. The most common missense mutation of BRAF (mainly V600E) contributes to the incidence of various cancers, including Langerhans cell histiocytosis (LCH). BRAF inhibitors molecularly targeting the… (More)
DOI: 10.1186/s13000-016-0489-z

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@inproceedings{Tatsuno2016BRAFVM, title={BRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay}, author={Michiko Tatsuno and Yoko Shioda and Hideto Iwafuchi and Shigeki Yamazaki and Kenta Iijima and Chiaki Takahashi and Hiromi Ono and Kiyono Uchida and Osamu Okamura and Mamoru Matubayashi and Torayuki Okuyama and Kimikazu Matsumoto and Takako Yoshioka and Atsuko Nakazawa}, booktitle={Diagnostic pathology}, year={2016} }