BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage.

@article{Mar2013BRAFNRASWM,
  title={BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage.},
  author={Victoria J. Mar and Stephen Q. Wong and Jason Li and Richard A Scolyer and Catriona Mclean and Anthony T. Papenfuss and Richard W. Tothill and Hojabr Kakavand and Graham J. Mann and John F Thompson and Andreas Behren and Jonathan Simon Cebon and Rory Wolfe and John William Kelly and Alexander Dobrovic and Grant Mcarthur},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 17},
  pages={4589-98}
}
PURPOSE The mutation load in melanoma is generally high compared with other tumor types due to extensive UV damage. Translation of exome sequencing data into clinically relevant information is therefore challenging. This study sought to characterize mutations identified in primary cutaneous melanomas and correlate these with clinicopathologic features. EXPERIMENTAL DESIGN DNA was extracted from 34 fresh-frozen primary cutaneous melanomas and matched peripheral blood. Tumor histopathology was… CONTINUE READING
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