BR55: a lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis.

@article{Pochon2010BR55AL,
  title={BR55: a lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis.},
  author={Sibylle Pochon and Isabelle Tardy and Philippe Bussat and Thierry Bettinger and Jean Brochot and Mathew A von Wronski and Lisa Passantino and Michel Schneider},
  journal={Investigative radiology},
  year={2010},
  volume={45 2},
  pages={
          89-95
        }
}
OBJECTIVES BR55, an ultrasound contrast agent functionalized with a heterodimer peptide targeting the vascular endothelial growth factor receptor 2 (VEGFR2), was evaluated in vitro and in vivo, demonstrating its potential for specific tumor detection. MATERIALS AND METHODS The targeted contrast agent was prepared by incorporation of a biospecific lipopeptide into the microbubble membrane. Experiments were performed in vitro to demonstrate the binding capacities of BR55 microbubbles on… CONTINUE READING
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