BQ-153, a novel endothelin (ET)A antagonist, attenuates the renal vascular effects of endothelin-1.

Abstract

Endothelin (ET)-1, leukotriene D4 and the thromboxane analogue, U-44069, were all shown to produce dose-dependent reductions in renal blood flow after direct injection into the renal artery of anaesthetized pigs. The effects of ET-1 differed from the other two mediators in that ET-1 caused a transient vasodilator followed by a prolonged vasoconstrictor… (More)

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