Corpus ID: 29983038

BQ-123 inhibits both endothelin 1 and endothelin 3 mediated C6 rat glioma cell proliferation suggesting an atypical endothelin receptor.

@article{Sedo1993BQ123IB,
  title={BQ-123 inhibits both endothelin 1 and endothelin 3 mediated C6 rat glioma cell proliferation suggesting an atypical endothelin receptor.},
  author={Sedo and P. Provero and R. Revoltella and V. Di Bartolo and P. Beffy and J. Mizrahi},
  journal={Journal of biological regulators and homeostatic agents},
  year={1993},
  volume={7 3},
  pages={
          95-8
        }
}
  • Sedo, P. Provero, +3 authors J. Mizrahi
  • Published 1993
  • Biology, Medicine
  • Journal of biological regulators and homeostatic agents
The mitogenic action of endothelins (ETs) 1 and 3 was studied on C6 rat glioma cells in serum-free culture conditions. In order to characterize the ET receptor subtype involved in this effect, BQ-123, and ETA receptor selective antagonist was used. Our results confirmed that both ET-1 and ET-3 are mitogenic peptides for C6 cells and demonstrated for the first time that the ETA receptor antagonist BQ-123 inhibits the proliferative effect of both ET-1 and ET-3 in this cellular system, providing… Expand
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