BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells

@inproceedings{Frey2017BPTFMC,
  title={BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells},
  author={Wesley D. Frey and Anisha Chaudhry and Priscila F. Slepicka and Adam M. Ouellette and Steven E. Kirberger and William C K Pomerantz and Gregory J Hannon and Camila Oresco dos Santos},
  booktitle={Stem cell reports},
  year={2017}
}
Chromatin remodeling is a key requirement for transcriptional control of cellular differentiation. However, the factors that alter chromatin architecture in mammary stem cells (MaSCs) are poorly understood. Here, we show that BPTF, the largest subunit of the NURF chromatin remodeling complex, is essential for MaSC self-renewal and differentiation of mammary epithelial cells (MECs). BPTF depletion arrests cells at a previously undefined stage of epithelial differentiation that is associated with… CONTINUE READING
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