BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine

@article{Chao2019BPR1M97AD,
  title={BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine},
  author={Po-Kuan Chao and Hsiao-Fu Chang and Wan-Ting Chang and Teng-Kuang Yeh and Shiu-Hwa Yeh},
  journal={Neuropharmacology},
  year={2019},
  pages={
          107678
        }
}
There is unmet need to design an analgesic with fewer side effects for severe pain management. Although traditional opioids are the most effective painkillers, they are accompanied by severe adverse responses, such as respiratory depression, constipation symptoms, tolerance, withdrawal, and addiction. We indicated BPR1M97 as a dual mu opioid receptor (MOP)/nociceptin-orphanin FQ peptide (NOP) receptor full agonist and investigated the pharmacology of BPR1M97 in multiple animal models. In vitro… CONTINUE READING
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