BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

@inproceedings{Cheung2011BPR1K653AN,
  title={BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells},
  author={Chun Hei Antonio Cheung and Wen-Hsing Lin and John Tsu-An Hsu and T C Hour and T I Yeh and Shengkai Ko and Tzu-Wen Lien and Mohane Selvaraj Coumar and Jin-fen Liu and Wen-yang Lai and Hui-Yi Shiao and T Lee and H. I. Hsieh and J. Y. Chang},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Over-expression of Aurora kinases promotes the tumorigenesis of cells. The aim of this study was to determine the preclinical profile of a novel pan-Aurora kinase inhibitor, BPR1K653, as a candidate for anti-cancer therapy. Since expression of the drug efflux pump, MDR1, reduces the effectiveness of various chemotherapeutic compounds in human cancers, this study also aimed to determine whether the potency of BPR1K653 could be affected by the expression of MDR1 in cancer cells… CONTINUE READING
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