BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.

@article{Hamill2009BPAG1eMK,
  title={BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.},
  author={Kevin J Hamill and Susan B Hopkinson and Philip Debiase and Jonathan C R Jones},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 12},
  pages={
          2954-62
        }
}
alpha6beta4 integrin, a component of hemidesmosomes, also plays a role in keratinocyte migration via signaling through Rac1 to the actin-severing protein cofilin. Here, we tested the hypothesis that the beta4 integrin-associated plakin protein, bullous pemphigoid antigen 1e (BPAG1e) functions as a scaffold for Rac1/cofilin signal transduction. We generated keratinocyte lines exhibiting a stable knockdown in BPAG1e expression. Knockdown of BPAG1e does not affect expression levels of other… CONTINUE READING

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