BP1 Homeoprotein Enhances Metastatic Potential in ER-negative Breast Cancer

  title={BP1 Homeoprotein Enhances Metastatic Potential in ER-negative Breast Cancer},
  author={Yebo Fu and Yi Lian and Kyung Soon Kim and Lei Zhang and A. Katharine Hindle and Fredrick J Brody and Robert S. Siegel and Timothy A. McCaffrey and Sidney W. Fu},
  booktitle={Journal of Cancer},
Tumor invasion and metastasis remain a major cause of mortality in breast cancer patients. It was reported that BP1, a homeobox isoform of DLX4, is overexpressed in 80% of breast cancer patients and in 100% of estrogen receptor negative (ER-) tumors. The prevalence of BP1 positive cells and the intensity of BP1 immunoreactivity increased with the extent of ductal proliferation and tumorigenesis. These findings imply that BP1 may play an important role in ER- breast cancer. We sought to… CONTINUE READING


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