Corpus ID: 23373542

BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.

  title={BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene.},
  author={Michael B. Chase and S Fu and Susanne B. Haga and Gregory J Davenport and Holly Stevenson and Khanh V. Do and Doris A. Morgan and Alex L. Mah and Patricia E. Berg},
  journal={Molecular and cellular biology},
  volume={22 8},
In earlier studies we identified a putative repressor of the human beta-globin gene, termed beta protein 1 (BP1), which binds to two silencer DNA sequences upstream of the adult human beta-globin gene and to a negative control region upstream of the adult delta-globin gene. Further studies demonstrated an inverse correlation between the binding affinity of the BP1 protein for the distal beta-globin silencer sequence and the severity of sickle cell anemia, suggesting a possible role for BP1 in… Expand
BP1 motif in the human beta-globin promoter affects beta-globin expression during embryonic/fetal erythropoiesis in transgenic mice bearing the human beta-globin gene.
In vivo observations support the contention that the BP1 binding site of the beta-globin promoter plays an important role in the regulation of transcription of the adult beta- globin gene. Expand
Recruitment of coregulator complexes to the β‐globin gene locus by TFII‐I and upstream stimulatory factor
The antagonistic activities of upstream stimulatory factor and TFII‐I on β‐globin gene expression are mediated at least in part by protein complexes that render the promoter associated chromatin accessible or inaccessible for the transcription complex. Expand
Genome-wide Analysis of BP1 Transcriptional Targets in Breast Cancer Cell Line Hs578T
Seven candidate target genes and gene networks, which are directly regulated by BP1 in ER negative breast cancer cells, are identified through chromatin immunoprecipitation on chip and gene expression microarray assays to identify potential transcriptional targets of BP1 via whole genome-scale screening. Expand
Overexpression of BP1, a homeobox gene, is associated with resistance to all-trans retinoic acid in acute promyelocytic leukemia cells
Comparing the growth-inhibitory and cyto-differentiating activities of all-trans retinoic acid (ATRA) in NB4 and R4 acute promyelocytic leukemia (APL) cells relative to BP1 levels suggests that BP1 is a potential therapeutic target in APL. Expand
BP1, an Isoform of DLX4 Homeoprotein, Negatively Regulates BRCA1 in Sporadic Breast Cancer
  • Brian Kluk, Y. Fu, +8 authors S. Fu
  • Biology, Medicine
  • International journal of biological sciences
  • 2010
Although further functional studies are necessary to confirm its repressor activity towards BRCA1, the elucidation of the role of BP1 in breast tumorigenesis holds great promise in establishing BP1 as a novel target for drug therapy. Expand
The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling
It is identified that expression of DLX4, a transcription factor encoded by a homeobox gene, increases during megakaryopoiesis but decreases during erythroid transcriptional program, and exerts opposing effects on themegakaryocytic and erystroid lineages in part by inducing IL-1β and NF-κB signaling. Expand
Expression of BP1, a novel homeobox gene, correlates with breast cancer progression and invasion
Findings suggest that BP1 is an important upstream factor in an oncogenic pathway, and that expression of BP1 may reliably reflect or directly contribute to tumor progression and/or invasion. Expand
Strong linkage disequilibrium of a HbE variant with the (AT)9(T)5 repeat in the BP1 binding site upstream of the β-globin gene in the Thai population
It is found that the HbE variant is in strong linkage disequilibrium with the (AT)9(T)5 allele, which can explain why the βE chain is inefficiently synthesized compared to the normal βA chain. Expand
BP1 transcriptionally activates bcl-2 and inhibits TNFα-induced cell death in MCF7 breast cancer cells
Mechanisms by which increased BP1 may impart a survival advantage to breast cancer cells, which could lead to increased resistance to therapeutic agents in patients are suggested. Expand
Distal-less homeobox transcription factors regulate development and maturation of natural killer cells
Natural killer (NK) cells constitute a subpopulation of lymphocytes that develop from precursors in the bone marrow (BM), but the transcriptional regulation of their development and maturation isExpand