BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells

@inproceedings{Renaud2011BORISCTCFLmediatedTR,
  title={BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerase gene in testicular and ovarian tumor cells},
  author={St{\'e}phanie Renaud and Dmitri I. Loukinov and Loredana Alberti and Alexander Vostrov and Y T Kwon and Fred T. Bosman and Victor V. Lobanenkov and Jean Benhattar},
  booktitle={Nucleic acids research},
  year={2011}
}
Telomerase activity, not detectable in somatic cells but frequently activated during carcinogenesis, confers immortality to tumors. Mechanisms governing expression of the catalytic subunit hTERT, the limiting factor for telomerase activity, still remain unclear. We previously proposed a model in which the binding of the transcription factor CTCF to the two first exons of hTERT results in transcriptional inhibition in normal cells. This inhibition is abrogated, however, by methylation of CTCF… CONTINUE READING
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