BONE FORMATION AND RESORPTION AS THE DETERMINANTS OF TRABECULAR BONE VOLUME IN POSTMENOPAUSAL OSTEOPOROSIS

@article{Nordin1981BONEFA,
  title={BONE FORMATION AND RESORPTION AS THE DETERMINANTS OF TRABECULAR BONE VOLUME IN POSTMENOPAUSAL OSTEOPOROSIS},
  author={B. E. Christopher Nordin and R. Speed and Jean E. Aaron and Richard G. Crilly},
  journal={The Lancet},
  year={1981},
  volume={318},
  pages={277-279}
}

Bone Formation and Resorption as the Determinants of Trabecular Bone Volume in Normal and Osteoporotic Men

Age-related (simple) osteoporosis in men appears to be due to reduced bone formation whereas pathological (accelerated) osteOPorosis is due to increased bone resorption.

Bone remodelling in osteoporosis

The observed changes in bone remodelling in osteoporotic postmenopausal women are an exaggeration of those observed during ageing, and these changes should be a basis for a coherent therapy of bone loss in osteOPorotic patients.

Decreased bone formation in osteoporotic patients compared with age-matched controls

Data indicate that decreased bone formations is a major contributing factor leading to trabecular bone loss in postmenopausal osteoporosis.

Trabecular and endocortical bone remodeling in postmenopausal osteoporosis: Comparison with normal postmenopausal women

The analysis of bone remodeling and structure parameters demonstrated that PMOp is a disease affecting both the cancellous and the endocortical envelopes and characterized by increased resorption and by a marked decrease in the osteoblastic apposition rate due to a reduced duration of bone formation.

Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.

The data indicate that age-related bone loss occurs principally by a process that removes entire structural elements of bone; those that remain are more widely separated and some may undergo compensatory thickening, but most slowly become reduced in thickness.

Active bone turnover of the cortico-endosteal envelope in postmenopausal osteoporosis.

It is suggested that patients with postmenopausal osteoporosis have active bone turnover at the cortico-endosteal envelope which may contribute significantly to bone loss in this disease.

Cancellous bone remodeling in type i (postmenopausal) osteoporosis: Quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels

ABSTRACT: The cellular mechanisms for bone loss in type I (postmenopausal) osteoporosis are highly controversial. We attempted to resolve this by assessing rates of formation and resorption of iliac

Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): a positive remodeling imbalance favoring bone formation

It is suggested that the increased cancellous bone mass seen in cases of cOA is due to increased bone formation rather than decreased bone resorption, which might contribute to the protection against fracture associated with the condition.

Bone marrow plays a role in bone metabolism: Histomorphometry of iliac bone in postmenopausal women

It is suggested that a change in the bone marrow, that is, a decrease in hematopoietic tissue, causes an imbalance in bone formation and resorption and leads to bone loss.

Cortical Bone Resorption in Osteoporosis

These figures reflect the importance of bone resorption, as opposed to deficient bone formation, as a cause of osteoporosis.
...

References

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Clinical Significance and Pathogenesis of Osteoporosis*

Femoral neck fractures in old people reflect the further progression of osteoporosis with advancing age since the fracture rate is inversely correlated with the mean thickness of the metacarpal cortex in the normal population.

POSTMENOPAUSAL OSTEOPOROSIS: ITS CLINICAL FEATURES

The existence of postmenopausal osteoporosis is pointed out and its clinical features described and some metabolic data showing the effects of therapy with estrogens and other agents are incorporated in other papers.

A unified concept of osteoporosis.

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