BONE FORMATION AND RESORPTION AS THE DETERMINANTS OF TRABECULAR BONE VOLUME IN POSTMENOPAUSAL OSTEOPOROSIS

@article{Nordin1981BONEFA,
  title={BONE FORMATION AND RESORPTION AS THE DETERMINANTS OF TRABECULAR BONE VOLUME IN POSTMENOPAUSAL OSTEOPOROSIS},
  author={B. E. Christopher Nordin and R. Speed and Jean E. Aaron and Richard G. Crilly},
  journal={The Lancet},
  year={1981},
  volume={318},
  pages={277-279}
}
Histomorphometry has been applied to trabecular bone samples obtained post-mortem from young and old women without known bone disease and to bone biopsy specimens from patients with postmenopausal osteoporosis. Bone volume was significantly lower in the old than young controls and significantly lower again in the osteoporotics. The loss of bone with age associated with a rise in surface resorption but no change in forming surface, and the further loss in osteoporotics was associated with a… Expand
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Bone Formation and Resorption as the Determinants of Trabecular Bone Volume in Normal and Osteoporotic Men
TLDR
Age-related (simple) osteoporosis in men appears to be due to reduced bone formation whereas pathological (accelerated) osteOPorosis is due to increased bone resorption. Expand
Bone remodelling in osteoporosis
TLDR
The observed changes in bone remodelling in osteoporotic postmenopausal women are an exaggeration of those observed during ageing, and these changes should be a basis for a coherent therapy of bone loss in osteOPorotic patients. Expand
Decreased bone formation in osteoporotic patients compared with age-matched controls
TLDR
Data indicate that decreased bone formations is a major contributing factor leading to trabecular bone loss in postmenopausal osteoporosis. Expand
Trabecular and endocortical bone remodeling in postmenopausal osteoporosis: Comparison with normal postmenopausal women
TLDR
The analysis of bone remodeling and structure parameters demonstrated that PMOp is a disease affecting both the cancellous and the endocortical envelopes and characterized by increased resorption and by a marked decrease in the osteoblastic apposition rate due to a reduced duration of bone formation. Expand
Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.
TLDR
The data indicate that age-related bone loss occurs principally by a process that removes entire structural elements of bone; those that remain are more widely separated and some may undergo compensatory thickening, but most slowly become reduced in thickness. Expand
Active bone turnover of the cortico-endosteal envelope in postmenopausal osteoporosis.
TLDR
It is suggested that patients with postmenopausal osteoporosis have active bone turnover at the cortico-endosteal envelope which may contribute significantly to bone loss in this disease. Expand
Cancellous bone remodeling in type i (postmenopausal) osteoporosis: Quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels
ABSTRACT: The cellular mechanisms for bone loss in type I (postmenopausal) osteoporosis are highly controversial. We attempted to resolve this by assessing rates of formation and resorption of iliac… Expand
Impaired osteoblast function in osteoporosis: comparison between calcium balance and dynamic histomorphometry.
TLDR
The mechanisms that regulate the effective life span of mature osteoblasts require further investigation, particularly as some promising treatments that can increase trabecular bone volume in osteoporosis, such as parathyroid peptide hPTH and sodium fluoride, must work through a reversal of osteoblastic depression. Expand
Increased cancellous bone in the femoral neck of patients with coxarthrosis (hip osteoarthritis): a positive remodeling imbalance favoring bone formation
TLDR
It is suggested that the increased cancellous bone mass seen in cases of cOA is due to increased bone formation rather than decreased bone resorption, which might contribute to the protection against fracture associated with the condition. Expand
Regional variations in histomorphometric bone dynamics from the skeleton of an osteoporotic woman
TLDR
It is suggested that bone biopsy in individual patients should not be the only basis for therapeutic decisions in postmenopausal osteoporosis and amount of hematopoietic marrow does not seem to influence bone formation. Expand
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