BON cells display the intestinal pattern of neurotensin/neuromedin N precursor processing

  title={BON cells display the intestinal pattern of neurotensin/neuromedin N precursor processing},
  author={R. Carraway and S. P. Mitra and B. Evers and C. Townsend},
  journal={Regulatory Peptides},
  • R. Carraway, S. P. Mitra, +1 author C. Townsend
  • Published 1994
  • Biology, Medicine
  • Regulatory Peptides
  • Antisera towards the bioactive peptides, neurotensin (NT, 13 residues) and neuromedin N (NMN, 6 residues), as well as towards three regions of their 147-residue canine precursor were used to identify and to quantitate precursor-derived peptides in extracts of human BON cells. This cell-line, which was obtained from a human pancreatic carcinoid tumor, constitutively expresses NT/NMN mRNA and secretes NT. Quantitation of seven precursor-derived peptides led us to conclude that BON cells display… CONTINUE READING
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