BOLD-fMRI of PTZ-induced seizures in rats.

  title={BOLD-fMRI of PTZ-induced seizures in rats.},
  author={Bart Keogh and Dietmar Cordes and Lawrence R Stanberry and Bradley D. Figler and Carol A. Robbins and Bruce L. Tempel and Christopher G. Green and Adriana Emmi and Kenneth Maravilla and Philip A. Schwartzkroin},
  journal={Epilepsy research},
  volume={66 1-3},
PURPOSE To develop a non-invasive method for exploring seizure initiation and propagation in the brain of intact experimental animals. METHODS We have developed and applied a model-independent statistical method--Hierarchical Cluster Analysis (HCA)--for analyzing BOLD-fMRI data following administration of pentylenetetrazol (PTZ) to intact rats. HCA clusters voxels into groups that share similar time courses and magnitudes of signal change, without any assumptions about when and/or where the… CONTINUE READING