BOLD contrast sensitivity enhancement and artifact reduction with multiecho EPI: parallel-acquired inhomogeneity-desensitized fMRI.

@article{Poser2006BOLDCS,
  title={BOLD contrast sensitivity enhancement and artifact reduction with multiecho EPI: parallel-acquired inhomogeneity-desensitized fMRI.},
  author={Benedikt A. Poser and Maarten J. Versluis and Johannes M. Hoogduin and David G. Norris},
  journal={Magnetic resonance in medicine},
  year={2006},
  volume={55 6},
  pages={1227-35}
}
Functional MRI (fMRI) generally employs gradient-echo echo-planar imaging (GE-EPI) to measure blood oxygen level-dependent (BOLD) signal changes that result from changes in tissue relaxation time T(*) (2) between activation and rest. Since T(*) (2) strongly varies across the brain and BOLD contrast is maximal only where the echo time (TE) equals the local T(*) (2), imaging at a single TE is a compromise in terms of overall sensitivity. Furthermore, the long echo train makes EPI very sensitive… CONTINUE READING
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