BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

@article{Llambi2016BOKIA,
  title={BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation},
  author={Fabien Llambi and Yuliang Wang and Bernadette Caroline Victor and Mao Xin Yang and Desiree M. Schneider and S{\'e}bastien Gingras and Melissa J Parsons and Janet H. Zheng and Scott Anthony Brown and Stephane Pelletier and Tudor Moldoveanu and Taosheng Chen and Douglas R Green},
  journal={Cell},
  year={2016},
  volume={165},
  pages={421-433}
}
The mitochondrial pathway of apoptosis is initiated by mitochondrial outer membrane permeabilization (MOMP). The BCL-2 family effectors BAX and BAK are thought to be absolutely required for this process. Here, we report that BCL-2 ovarian killer (BOK) is a bona fide yet unconventional effector of MOMP that can trigger apoptosis in the absence of both BAX and BAK. However, unlike the canonical effectors, BOK appears to be constitutively active and unresponsive to antagonistic effects of the… CONTINUE READING
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