BOAA selectively enhances L-glutamate release from guinea pig hippocampal mossy fiber synaptosomes.

@article{Gannon1989BOAASE,
  title={BOAA selectively enhances L-glutamate release from guinea pig hippocampal mossy fiber synaptosomes.},
  author={Robert L. Gannon and David M. Terrian},
  journal={Neuroscience letters},
  year={1989},
  volume={107 1-3},
  pages={289-94}
}
The neurotoxic amino acids beta-N-oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were evaluated for possible effects on spontaneous and stimulus-evoked release of L-glutamate (L-Glu) and dynorphin A(1-8)-like immunoreactivity (LI) from guinea pig hippocampal mossy fiber synaptosomes. BOAA (200 microM), but not BMAA (1 mM), was found to significantly increase both basal cytosolic and KCl-stimulated vesicular release of L-Glu. Neither BOAA nor BMAA had any effect on… CONTINUE READING