BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the “weaver” mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor

@article{Botsakis2017BNN20AS,
  title={BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the “weaver” mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor},
  author={K. Botsakis and Theodora Mourtzi and Vasiliki Panagiotakopoulou and Malamati Vreka and F. Angelatou},
  journal={Neuropharmacology},
  year={2017},
  volume={121},
  pages={140-157}
}
  • K. Botsakis, Theodora Mourtzi, +2 authors F. Angelatou
  • Published 2017
  • Chemistry, Medicine
  • Neuropharmacology
  • Neurotrophic factors are among the most promising treatments aiming at slowing or stopping and even reversing Parkinson's disease (PD). However, in most cases, they cannot readily cross the human blood-brain-barrier (BBB). Herein, we propose as a therapeutic for PD the small molecule 17-beta-spiro-[5-androsten-17,2'-oxiran]-3beta-ol (BNN-20), a synthetic analogue of DHEA, which crosses the BBB and is deprived of endocrine side-effects. Using the "weaver" mouse, a genetic model of PD, which… CONTINUE READING
    7 Citations
    Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson’s Disease
    • W. Jin
    • Medicine
    • Journal of clinical medicine
    • 2020
    • 7
    • PDF
    Neurosteroids as regulators of neuroinflammation
    • 17

    References

    SHOWING 1-10 OF 120 REFERENCES
    The TrkB-Positive Dopaminergic Neurons are Less Sensitive to MPTP Insult in the Substantia Nigra of Adult C57/BL Mice
    • 23
    Metallothionein-mediated neuroprotection in genetically engineered mouse models of Parkinson's disease.
    • 94
    • PDF
    Neuroprotective Effect of Progesterone in MPTP-Treated Male Mice
    • 19
    • PDF
    Changes in cytokines and neurotrophins in Parkinson's disease.
    • 412