BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore.

@article{Velde2000BNIP3AG,
  title={BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore.},
  author={Christine Vande Velde and Jeannick Cizeau and Don Dubik and Judie Alimonti and Thomas Brown and Sara J. Israels and Razqallah Hakem and Arnold H. Greenberg},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 15},
  pages={5454-68}
}
Many apoptotic signaling pathways are directed to mitochondria, where they initiate the release of apoptogenic proteins and open the proposed mitochondrial permeability transition (PT) pore that ultimately results in the activation of the caspase proteases responsible for cell disassembly. BNIP3 (formerly NIP3) is a member of the Bcl-2 family that is expressed in mitochondria and induces apoptosis without a functional BH3 domain. We report that endogenous BNIP3 is loosely associated with… CONTINUE READING
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