BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory.

@article{OSullivan2015BNIP3AB,
  title={BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory.},
  author={Timothy E O'Sullivan and Lexus R Johnson and Helen Hwang Grace Hyejin Jae Christophe Jauffret Raquel Kang and Joseph C Sun},
  journal={Immunity},
  year={2015},
  volume={43 2},
  pages={331-42}
}
Natural killer (NK) cells are innate lymphocytes that possess traits of adaptive immunity, such as clonal expansion, contraction, and generation of long-lived "memory" cells, processes poorly understood at the molecular level. Here, we found that as proliferating NK cells accumulated dysfunctional mitochondria during viral infection, a protective mitophagy pathway was induced during the contraction phase to promote their survival in a reactive oxygen species (ROS)-dependent manner. Inhibition… CONTINUE READING
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The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

  • A. Marçais, J. Cherfils-Vicini, +7 authors J Bienvenu
  • Nat. Immunol
  • 2014
Highly Influential
4 Excerpts

fitness in natural killer cells

  • J. Kim, M. Kundu, B. Viollet, K. L. Guan
  • 2011
Highly Influential
13 Excerpts

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