BNIP 3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non – Small Cell Lung Cancer

@inproceedings{Giatromanolaki2004BNIP3E,
  title={BNIP 3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non – Small Cell Lung Cancer},
  author={Alexandra N Giatromanolaki and Michael I. Koukourakis and Heidi Michelle Sowter and Efthimios L Sivridis and Spencer Gibson and Kevin C. Gatter and Adrian L. Harris},
  year={2004}
}
BNIP3 is a proapoptotic protein regulated by hypoxiainducible factor 1. We analyzed BNIP3 expression in 105 tumor samples from early operable, non-small lung cancer and the relationship of expression to hypoxia-inducible factor 1 , other hypoxia-regulated pathways, and prognosis. There was strong cytoplasmic expression in >10% of cells in 40 of 105 cases. BNIP3 expression was associated significantly with high hypoxia-inducible factor 1 (P 0.003), carbonic anhydrase 9 (P 0.04), and was… CONTINUE READING
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poxia and acidosis activate cardiac myocyte death through the Bcl - 2 family protein BNIP 3

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