BNCT for locally recurrent head and neck cancer: preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor.

@article{Wang2011BNCTFL,
  title={BNCT for locally recurrent head and neck cancer: preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor.},
  author={Ling-wei Wang and Shyh-Jen Wang and Pen Yuan Chu and C Y Ho and S H Jiang and Y W H Liu and H. M. Liu and J J Peir and F I Chou and S. H. Yen and Y L Lee and C W Chang and Chuan Sheng Liu and Y W Chen and Koji Ono},
  journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine},
  year={2011},
  volume={69 12},
  pages={1803-6}
}
To introduce our preliminary experience of treating locally and regionally recurrent Head and Neck cancer patients at Tsing Hua Open-Pool Reactor in Taiwan, four patients (M/F=3/1, median age 68 Y/O) were enrolled. BNCT with BPA (400 mg/kg) injected in 2 phases and prescription dose of 12-35 Gy (Eq.)/fraction for 2 fractions at 30 day interval can be given with sustained blood boron concentration and tolerable early toxicities for recurrent H & N cancer.