• Corpus ID: 92020905

BMY 20064, a potent calcium channel blocker with. cap alpha. /sub 1/-adrenoceptor antagonist properties

@inproceedings{Stanton1986BMY2A,
  title={BMY 20064, a potent calcium channel blocker with. cap alpha. /sub 1/-adrenoceptor antagonist properties},
  author={H. C. Stanton and L. Rosenberger and R. Hanson and J. Fleming and Poindexter Gs},
  year={1986}
}
BMY 20064 ((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)-methyl 1,4-dihydro-2-6-dimethyl-4-(3-nitrophenyl)-3-5-pyridinedicarboxylate) is a new Ca/sup +2/ channel blocking agent equivalent in activity to nifedipine in the isolated K/sup +/ depolarized rat aorta. It is also an ..cap alpha../sub 1/ selective antagonist (0.17x prazosin) in a radioligand binding assay. BMY 20064 (10-/sup 7/M) was more effective than nifedipine (10/sup -7/M) in antagonizing net increases in /sup 45/Ca/sup +2/ uptake…