BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro.

@article{Dai2010BMS777607AS,
  title={BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro.},
  author={Yao Dai and Dietmar W. Siemann},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 6},
  pages={1554-61}
}
Most prostate cancer-related deaths are due to advanced disease with patients with metastatic prostate cancer having a 5-year survival rate of only 34%. Overexpression of c-Met receptor tyrosine kinase has been highly associated with prostate cancer progression and metastasis. In the present studies, the effect of BMS-777607, a selective and potent small-molecule Met kinase inhibitor that has been advanced to clinical evaluation, on hepatocyte growth factor (HGF)-mediated cell functions and… CONTINUE READING
27 Citations
47 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Hepatocyte growth factor Molecular Cancer Therapeutics

  • PA Humphrey, X Zhu, R Zarnegar
  • Am J Pathol
  • 2010
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…