BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies.

@article{Wong2010BMS593214AA,
  title={BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies.},
  author={Pancras C. Wong and Joseph M. Luettgen and Alan R. Rendina and Charles A. Kettner and Baomin Xin and Robert M. Knabb and Ruth R Wexler and E Scott Priestley},
  journal={Thrombosis and haemostasis},
  year={2010},
  volume={104 2},
  pages={261-9}
}
Factor (F) VIIa in association with tissue factor (TF) is the primary in vivo initiator of blood coagulation and activates FX and FIX to generate thrombin, which plays a key role in the pathogenesis of thrombosis. We evaluated the enzyme kinetics, antithrombotic and antihaemostatic properties of BMS-593214, an active-site, direct FVIIa inhibitor. Studies were conducted in enzymatic assays, and in anesthetised rabbit models of electrically-induced carotid arterial thrombosis (AT), thread-induced… CONTINUE READING