BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174.

@article{Dickinson1994BMS180560AI,
  title={BMS-180560, an insurmountable inhibitor of angiotensin II-stimulated responses: comparison with losartan and EXP3174.},
  author={Kenneth Ernest John. Dickinson and Robert B. Cohen and Stephen Skwish and Christopher L. Delaney and Randy Serafino and Michael A. Poss and Zhen-yong Gu and Denis Evan Ryono and Suzanne Moreland and Jonathan Raymond Powell},
  journal={British journal of pharmacology},
  year={1994},
  volume={113 1},
  pages={
          179-89
        }
}
1. This study compares the activity of BMS-180560 (2-butyl-1-chloro-1-[[1-[2-(2H-tetrazol-5-yl)phenyl]-1H-indol-4- yl]methyl]-1H-imidazole-5-carboxylic acid), an insurmountable angiotensin II (AII) receptor antagonist, with that of losartan and EXP3174 in functional and biochemical models of AII-receptor activation. 2. BMS-180560 selectively inhibited [125I]-Sar1Ile8AII ([125I]SI-AII) binding to rat aortic smooth muscle (RASM) cell and rat adrenal cortical AT1 receptors (Ki = 7.6 +/- 1.2 and 18… CONTINUE READING
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