BMPs mediate lateral inhibition at successive stages in feather tract development.

  title={BMPs mediate lateral inhibition at successive stages in feather tract development.},
  author={Selina Noramly and Bruce A. Morgan},
  volume={125 19},
The spacing of feather buds in a tract is thought to arise from the interaction between an inducing signal from the dermis and an inhibitory signal generated in the nascent buds. Local BMP-2 expression in the ectoderm precedes the formation of the ectodermal placodes, which are the first morphological sign of bud differentiation. We have altered the activity of BMP-2 or BMP-4 in the ectoderm of the feather field by expressing them or their inhibitor noggin using retroviral vectors. These… CONTINUE READING
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