BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury.

@article{Sahni2010BMPR1aAB,
  title={BMPR1a and BMPR1b signaling exert opposing effects on gliosis after spinal cord injury.},
  author={Vibhu Sahni and Abhishek Mukhopadhyay and Vicki M Tysseling and Amy R. T. H{\'e}bert and Derin V Birch and Tammy L. Mcguire and Samuel I. Stupp and John A Kessler},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 5},
  pages={1839-55}
}
Astrogliosis following spinal cord injury (SCI) involves an early hypertrophic response that is beneficial and a subsequent formation of a dense scar. We investigated the role of bone morphogenetic protein (BMP) signaling in gliosis after SCI and find that BMPR1a and BMPR1b signaling exerts opposing effects on hypertrophy. Conditional ablation of BMPR1a from glial fibrillary acidic protein (GFAP)-expressing cells leads to defective astrocytic hypertrophy, increased infiltration by inflammatory… CONTINUE READING

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