BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH.

@article{Nasim2012BMPRIIDE,
  title={BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH.},
  author={Md. Nasim and Takeshi Ogo and Hasnin M Chowdhury and Lan Zhao and Chien-Nien Chen and Christopher N Rhodes and Richard C Trembath},
  journal={Human molecular genetics},
  year={2012},
  volume={21 11},
  pages={2548-58}
}
Pulmonary arterial hypertension (PAH) is a cardiovascular disorder associated with enhanced proliferation and suppressed apoptosis of pulmonary arterial smooth muscle cells (PASMCs). Heterozygous mutations in the type II receptor for bone morphogenetic protein (BMPR2) underlie the majority of the inherited and familial forms of PAH. The transforming growth factor β (TGFβ) pathway is activated in both human and experimental models of PAH. However, how these factors exert pro-proliferative and… CONTINUE READING

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